Ontology highlight
ABSTRACT:
REANALYSED by: GSE25077
INSTRUMENT(S): Illumina humanRef-8 v2.0 expression beadchip
SUBMITTER: Lauro Sumoy
PROVIDER: GSE12299 | GEO | 2008-10-20
SECONDARY ACCESSION(S): PRJNA113597
REPOSITORIES: GEO
PLoS genetics 20081017 10
At least six histone H1 variants exist in somatic mammalian cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be actively involved in the regulation of gene expression. However, it is not well known whether the different variants have distinct roles or if they regulate specific promoters. We have explored this by inducible shRNA-mediated knock-down of each of the H1 variants in a human breast cancer ...[more]