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2-5A-Mediated mRNA Decay and Transcription Act in Concert to Reprogram Protein Synthesis during dsRNA Response

ABSTRACT: RNA degradation by RNase L during 2-5A-mediated decay (2-5AMD) is a conserved mammalian stress response to viral and endogenous double-stranded RNA (dsRNA). To understand this mechanism we examined 2-5AMD in human cells by spike-in RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123034 | GEO | 2018/11/29

REPOSITORIES: GEO

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