Genomics

Dataset Information

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Comparison of serum and saliva miRNAs for identification and characterization of mild Traumatic Brain Injury (mTBI) in adult mixed martial arts fighters


ABSTRACT: We evaluated the utility of serum and salivary microRNAs (miRNAs) to serve as sensitive and specific peripheral biomarkers of possible mTBI. Levels of miRNAs were obtained stranded small RNA-sequencing. Functional outcomes were evaluated using a computerized assessment system that measured cognitive performance, body sway, and combined cognitive performance and body sway during dual task completion. We identified a subset of salivary and serum miRNAs that showed robust utility at predicting TBI likelihood and demonstrated quantitative associations with head impacts as well as cognitive and balance measures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123336 | GEO | 2018/12/05

REPOSITORIES: GEO

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