Mouse Estrogen Treatment Study Analysis of Peri-prostatic Fat

ABSTRACT: Obesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Here, we tested the hypothesis that supplemental 17β-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE123357 | GEO | 2019/07/22

REPOSITORIES: GEO