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Comparison of low-fat and high-fat diet on gene expression in muscle, liver and adipose tissue from mice of two genetic backgrounds

ABSTRACT: Diet-induced obesity is the primary determinant of the current epidemic of diabetes. We have explored the role of genetics in this phenomenon, using C57Bl/6 (B6) and 129S6/SvEvTac (129) mice on a low- or high-fat diet. Microarray analysis indicated significant changes in expression levels between B6 and 129 mice in the chromosomal area of Wnt5a and protein kinase C delta (PKC-delta). Thus, caloric efficiency, i.e., the “thrifty gene,” is a dominant-acting genetic determinant of diet-induced obesity in mice and can be linked to a locus on chromosome 14, including genes linked to adipose development and insulin sensitivity.

ORGANISM(S): Mus musculus

PROVIDER: GSE123394 | GEO | 2018/12/11

REPOSITORIES: GEO

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