Expression data from oral squamous cell carcinomas, 3A and HO1-N-1

ABSTRACT: Co-culture with human oral squamous cell carcinoma cells, 3A or NEM, or culture with each of their conditioned medium induced many osteoclasts from osteoclast precursor cells, which were generated by a 24-h pretreatment of RANKL or TNF-α. However, HO1-N-1 cells did not induce any osteoclasts. Osteoprotegerin, a decoy RANKL receptor, denosumab, an anti-RANKL antibody drug, and infliximab, an anti-TNF-α antibody drug, did not prevent this tumor-associated osteoclastogenesis. We compared the expression of molecules associated with osteoclastogenesis between 3A and HO1-N-1 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123411 | GEO | 2019/01/09

REPOSITORIES: GEO