MEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling

ABSTRACT: Analysis of bone-marrow derived macrophages (BMDMs) stimulated with single or combinatorial TLR agonist and MEK1/2 inhibitor in wild-type and Irf1-/- macrophages. Results provide insights into the versatile but yet uncharacterized roles of IRF1 in TLR-MEK1/2-ERK MAPK signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE123512 | GEO | 2018/12/28

REPOSITORIES: GEO