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Functional dissection of MIEN1 trans-regulation provides new evidence for colorectal cancer genome editing-based therapeutics

ABSTRACT: MIEN1 has been described as a key actor in colorectal cancer (CRC) biogenesis. We have used CRISPR/Cas9 technique to delete the promoter region of MIEN1 in HT-29 CRC cells. RNA-seq experiments revealed that several biological processes related to migration/metastasis were enriched by differentially expressed genes. Genetically modified cells shown decreased migration capacity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123734 | GEO | 2020/12/12

REPOSITORIES: GEO

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