Sexually dimorphic role of constitutive androstane receptor in the regulation of endocrine and metabolic homeostasis

ABSTRACT: The constitutive androstane receptor (CAR) is a transcription factor involved in detoxification through regulating expression of xenobiotic-metabolizing enzymes. Highly expressed in the liver, it is important in protecting the organism against exogenous and endogenous toxic molecules such as bile acids and bilirubin and in the catabolism of thyroid and steroid hormones. A role has also been assigned to CAR in the regulation of energy metabolism, although related mechanisms have been studied primarily in males and in physiopathological conditions. Here, we compared the impact of CAR deficiency on energy homeostasis regulation between male and female mice in a normal physiological context. Large-scale gene expression analysis in 16-week-old animals revealed significant sexual dimorphism in the hepatic transcriptome of CAR-/- mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE123876 | GEO | 2020/01/02

REPOSITORIES: GEO