Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomic instability in the naturally and prematurely aged myocardium [RNA-Seq]

ABSTRACT: Our data demonstrate that genomic instability does not evidently contribute to naturally aging of the mouse heart and support the contention that the endogenous DNA repair machinery is remarkably active to maintain genomic integrity in cardiac cells throughout life.

ORGANISM(S): Mus musculus

PROVIDER: GSE124005 | GEO | 2021/09/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Genomic instability in the naturally and prematurely aged myocardium [variants: data set 2]

Project description:Our data demonstrate that genomic instability does not evidently contribute to naturally aging of the mouse heart and support the contention that the endogenous DNA repair machinery is remarkably active to maintain genomic integrity in cardiac cells throughout life.

2021-09-15 | GSE129278 | GEO

Genomic instability in the naturally and prematurely aged myocardium [variants: data set 1]

2021-09-15 | GSE124083 | GEO

Genomic instability in the naturally and prematurely aged myocardium

Project description:Genomic instability in the naturally and prematurely aged myocardium

| PRJNA510744 | ENA

Genomic instability in the naturally and prematurely aged myocardium [RNA-Seq]

Project description:Genomic instability in the naturally and prematurely aged myocardium [RNA-Seq]

| PRJNA510746 | ENA

Genomic instability in the naturally and prematurely aged myocardium [variants: data set 1]

Project description:Genomic instability in the naturally and prematurely aged myocardium [variants: data set 1]

| PRJNA510748 | ENA

Genomic instability in the naturally and prematurely aged myocardium [variants: data set 2]

Project description:Genomic instability in the naturally and prematurely aged myocardium [variants: data set 2]

| PRJNA530713 | ENA

Genomic instability in the naturally and prematurely aged myocardium

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-09-15 | GSE124087 | GEO

Aldehyde exposure unmasks genome instability in cells heterozygous for clinically relevant BRCA2 mutations

Project description:Abnormalities provoked in human cells heterozygous for clinically relevant truncating mutations in BRCA2 by their exposure to naturally occurring aldehydes define a mechanism promoting carcinogenesis in mutation carriers. The ubiquitous metabolite and environmental toxin, formaldehyde, triggers replication fork instability and structural chromosomal aberrations in BRCA2 heterozygous cells. These abnormalities arise from a previously unrecognized effect of formaldehyde to selectively induce the proteasomal degradation of BRCA2, inducing functional haploinsufficiency only in cells where BRCA2 expression is already compromised by a heterozygous mutation. Similar effects are observed with acetaldehyde, a toxic product of alcohol catabolism. Replication fork instability and chromosomal aberrations in aldehyde-exposed cells arise from the unscheduled accumulation of RNA-DNA hybrids, revealing a mechanism driving genomic instability in BRCA2 heterozygous cells. We propose a model for cancer pathogenesis in which aldehyde exposure unmasks the carcinogenic potential of heterozygous BRCA2 mutations, with public health implications in mutation carriers.

2017-06-02 | PXD006106 | Pride

Carbendazim induced genomic instability in yeast

Project description:Carbendazim induced genomic instability in yeast

| PRJNA439200 | ENA

Chronic p53-independent p21 expression deregulates replication licensing, leading to genomic instability

Project description:P53 independent P21 expression deregulates replication licensing , leading to genomic instability

2016-05-17 | PXD004140 | Pride