Genomics

Dataset Information

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CD56dim NK cell gene signature in melanoma patients with better and worse clinical outcomes


ABSTRACT: Natural killer (NK) cells are innate cytotoxic and immunoregulatory lymphocytes that have a central role in anti-tumor immunity and play a critical role in mediating cellular immunity in advanced cancer immunotherapies, such as dendritic cell (DC) vaccines. Our group recently tested a novel recombinant adenovirus-transduced autologous DC-based vaccine that simultaneously induces T cell responses against three melanoma-associated antigens for advanced melanoma patients. We examined the impact of this vaccine on the NK cell profile in melanoma patients. Relative immune cell population abundance was evaluated as previously described (Danaher et al. JITC, 2017). The abundance of the CD56dim NK cell gene signature was compared between pattients with better and worse outcome. Overall design: 41 lesions from 19 patients were excised at three different time-points during this trial and total RNA was extracted. Samples were profiled on the nCounter® MAX platform with the PanCancer Immune Profiling Panel

INSTRUMENT(S): NanoString nCounter human PanCancer Immune Profiling Panel (Custom Codeset)

ORGANISM(S): Homo sapiens  

SUBMITTER: Lazar Vujanovic 

PROVIDER: GSE124574 | GEO | 2019-01-03

REPOSITORIES: GEO

Dataset's files

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GSE124574_RAW.tar Raw
GSE124574_melanoma_patients_CD56dim_cell_profiles.txt.gz Txt
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Publications

CD56<sup>dim</sup> CD16<sup>-</sup> Natural Killer Cell Profiling in Melanoma Patients Receiving a Cancer Vaccine and Interferon-α.

Vujanovic Lazar L   Chuckran Christopher C   Lin Yan Y   Ding Fei F   Sander Cindy A CA   Santos Patricia M PM   Lohr Joel J   Mashadi-Hossein Afshin A   Warren Sarah S   White Andy A   Huang Alan A   Kirkwood John M JM   Butterfield Lisa H LH  

Frontiers in immunology 20190129


Natural killer (NK) cells are innate cytotoxic and immunoregulatory lymphocytes that have a central role in anti-tumor immunity and play a critical role in mediating cellular immunity in advanced cancer immunotherapies, such as dendritic cell (DC) vaccines. Our group recently tested a novel recombinant adenovirus-transduced autologous DC-based vaccine that simultaneously induces T cell responses against three melanoma-associated antigens for advanced melanoma patients. Here, we examine the impac  ...[more]

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