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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) [Hep1-6]

ABSTRACT: To address how serum cholesterol affected tumor progression, C57BL/6J mice were placed on either normal diet or high cholesterol diet for 4 weeks, and then Hep1-6 cells were subcutaneously injected into the right flanks of mice. We performed transcriptome sequencing analysis (RNA-seq) on tumor tissues from ND and HCD groups.

ORGANISM(S): Mus musculus

PROVIDER: GSE124599 | GEO | 2019/02/03

REPOSITORIES: GEO

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD)

Project description:To address how serum cholesterol affected tumor progression, C57BL/6J mice were placed on either normal diet or high cholesterol diet for 4 weeks, and then B16F10 cells were subcutaneously injected into the right flanks of mice. We performed transcriptome sequencing analysis (RNA-seq) on tumor tissues from ND and HCD groups.

2017-10-02 | GSE104463 | GEO

RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) II

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RNA-seq data for tumor tissues from mice fed with normal diet (ND) or high cholesterol diet (HCD) [Hep1-6]

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The effect of Lats2 knockout and diet on liver disease in mice

Project description:Liver samples of mice harboring liver-specific deletion of Lats2 (Lats2-CKO) were compared to WT mice. This effect was tested along with the effect of diet - high cholesterol diet (Paigen-PD) vs. normal chow (ND). Expression array analysis on Affymetrix microarrays was carried out for livers from WT and Lats2-CKO mice fed ND or HCD for 9 weeks.

2016-03-17 | E-GEOD-68824 | biostudies-arrayexpress

Transcriptome data of bone marrow long-term hematopoietic stem cells (LT-HSCs) from mice with or without 3-month high cholesterol diet (HCD) treatment

Project description:The vulnerability of bone marrow hematopoiesis to perturbations of cholesterol metabolism is well documented, while the underlying cellular and molecular mechanisms remain poorly understood. Here we reveal a distinct cholesterol metabolic signature of hematopoietic stem cells (HSCs) within the hematopoietic compartment.To identify the phenotype switching and function variation in BM LT-HSCs with HCD treatment, we performed RNA-seq of LT-HSCs from the bone marrow of mice with or without3-month HCD treatment.

2023-03-29 | GSE214035 | GEO

Effect of High Cholesterol Diet (HCD) on B cell subsets in atheroprone mice with or without myb deficiency

Project description:Splenic B cell subsets (IgM+CD138+ ASC, FO B cells, MZ+B1 B cells) sorted from 8 month LDL-r KO mice with or without c-myb hypomorphism fed a 12 week HCD diet

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The effect of Lats2 knockout and diet on liver disease in mice

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scRNAseq and TCRseq of hepatic and splenic CD8T cells from normal diet fed (ND), HFHC diet fed (HFHC), and resolution induced (RES) mice.

Project description:To explore key features associated with the resolution process in liver fibrosis, we here applied a unique murine model, in which mice were fed HFHC diet for 24 weeks, and then continued with the HFHC diet (HFHC) or switched to a normal diet (RES) for 5 weeks. We noted that both the frequency and number of intrahepatic CD8+ T cells remained significantly high in RES mice compared to normal diet-fed mice (ND). To reveal the transcriptome profiling-based subtypes of CD8+T cells present during the liver fibosis resolution, we performed scRNA-seq analysis. Total of 25851 cells were clustered into 17 clusters based on the gene signatures. We revealed CD69+CD103-CD8+ Trm cell enrichment in fibrosis resolution livers. scTCR-seq analysis further revealed the clonal enrichment mainly in the Cd44+Sell-S1pr1- liver Trm fractions. In addition, TCR clonotypes enriched in liver CD8+ Trm cells of RES mice were expanded compared to those in liver CD8+ T cells of ND mice, and rarely detected in spleen CD8+ T cells.

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