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Comprehensive transcriptional atlas of intestinal immune cells reveals that neuropeptide α-CGRP orchestrates ILC2 responses

ABSTRACT: We combine single-cell RNA sequencing (scRNA-seq) with physiological and genetic perturbations to dissect the cellular circuit of type 2 intestinal inflammation. To uncover key responding cellular components, we profiled individual immune cells in the lamina propria (LP) and Peyer’s patches (PPs), regions of the small intestine enriched for immune cells, in homeostasis and in an intestinal type 2 inflammatory model. We obtained 36,797 and 21,270 high-quality cells passing initial filtering from PP and LP regions, respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE124880 | GEO | 2019/10/16

REPOSITORIES: GEO

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