Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus

ABSTRACT: SLE patients exhibit increased interferon signatures in their skin secondary to increased production and a robust, skewed IFN response that is regulated by PITX1. Targeting of these exaggerated pathways may prove to be beneficial to prevent and treat hyperinflammatory responses in SLE skin.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124939 | GEO | 2019/01/15

REPOSITORIES: GEO