Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Refinement of BMYB function in response to androgenic stimulation reveals genomic and non-genomic roles involving possible fluid-phase transitions

ABSTRACT: We found a transient increase of BMYB in the prostate gland after castration and down regulation after LNCaP cells were treated to androgen (R1881). The BMYB interacts with chromatin forming large aggregates.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124957 | GEO | 2019/01/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Refinement of BMYB function in response to androgenic stimulation reveals genomic and non-genomic roles involving possible fluid-phase transitions

Project description:Refinement of BMYB function in response to androgenic stimulation reveals genomic and non-genomic roles involving possible fluid-phase transitions

| PRJNA514456 | ENA

Gene expression of LNCaP cells grown in polyethlene glycol-based hydrogels alone (monocultures) and grown with human osteoblasts as tissue engineered bone (co-culture) with the presence of synthetic androgen, R1881

2014-05-13 | GSE44143 | GEO

Identification of direct androgen-target genes in the prostate cancer cell line LNCaP

Project description:Transcriptional profiling of the LNCaP cell line treated with R1881 synthetic androgen and/or cycloheximide.

2014-06-14 | GSE22372 | GEO

Gene expression by AR agonism and AR antagonism in isotope-labeled PCa cells

Project description:Systematic investigation of gene expression by R1881 and Enzalutamide in SILAC assay of LNCaP cells

2025-03-28 | GSE279661 | GEO

Prostasphere-forming cells of human prostate cancer cell LNCaP: Control vs. Hormone treated

Project description:Transcriptional profiling of LNCaP prostasphere-forming cells, comparing control untreated sphere-forming cells with hormone treated sphere-forming cells. Both estrogen (estradiol) and androgen (R1881) promote the sphere formation of human prostate cancer cell LNCaP. Goal was to determine the effects of hormones on global gene expression of LNCaP sphere-forming cells. Five samples were analyzed. Control (ethanol 1hr), estradiol 1 hour, estradiol 24 hour, R1881 1 hour, R1881 24 hour.

2012-04-23 | E-GEOD-37531 | biostudies-arrayexpress

R1881 treatment modulates LNCaP proteome.

Project description:The androgen receptor is considered as the key promoter of prostate cancer. It is a transcription factor that controls the transcription of hundreds of its target genes. In this project we focuses on how androgen receptor stimulation by the synthetic androgen R1881 can affect the proteome of peroxiosmes and the antioxidant enzymes in LNCaP cells.

2024-11-01 | PXD054374 | Pride

Genome-wide RNA-sequencing (RNA-seq) of benign and malignant prostate cell lines without and with androgen (R1881) stimulation.

Project description:RNA-seq data were obtained from hTERT immortalized human prostate transit amplifying EP156T cells (+/- 10 nM R1881 for 48 hrs), progeny tumorigenic EPT3-M1 cells recovered from mouse metastatic tumor (+/- 10 nM R1881 for 48 hrs) and the prostate cancer cell lines LNCaP (+/- 10 nM R1881 for 48 hrs), VCaP (+/- 1 nM R1881 for 24 hrs) and 22Rv1 (+/- 1 nM R1881 for 24 hrs) (obtained from the American Type Culture Collection). All cells were either stimulated or not stimulated with the synthetic androgen R1881 (1 or 10 nM for 24 or 48 hrs) prior to lysis (Qiagen miRNeasy minikit lysis buffer) and total RNA purification and DNase treatment.

2017-02-09 | GSE71797 | GEO

Prostasphere-forming cells of human prostate cancer cell LNCaP: Control vs. Hormone treated

2012-04-24 | GSE37531 | GEO

Project description:Analysis of LNCaP cell molecular differences in monocultures and in co-cultures in the presence of R1881. Human osteoblast molecular signatures were also identified from the tissue engineered bone monocultures. LNCaP cells molecular profile was altered by co-culturing with human osteoblasts compared to LNCaP monocultures with or without R1881 stimulations. These results provide insights into the behavioral change of LNCaP cells in a bone-like microenvironment. In this study, LNCaP cells cultured in the hydrogel were prepared and co-cultured with or without human osteoblasts (in the form oftissue engineered bone). Similarly, tissue engineered bone monocultures were also prepared 4-6 weeks earlier before co-culturing with the LNCaP cells. These cultures were maintained up to 24 days in RPMI growth media (+10% FBS) before they were androgen-starved for 48 hours. Cells were either treated with 1nM R1881 or continued to be androgen-deprived (without R1881 with 0.008% ethanol) for another 48 hours prior to cell harvest for gene expression analysis. Biological triplicates were prepared for each condition.

2014-05-13 | E-GEOD-44143 | biostudies-arrayexpress

Gene expression of LNCaP cells grown in androgen deprived conditions in the presence of 10nM insulin and/or 1nM R1881.

Project description:Analysis of LNCaP cell molecular differences and their response to insulin compared to control or R1881. Insulin differentially regulated genes, as did R1881, though the treatments had a very different profile, with some overlaps. These results provide insights into the effect of insulin on cancer related pathways in an androgen deprived setting.

2017-06-07 | GSE47622 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data