Gene expression and chromatin accessibility of iLSCs vs iBlasts cells

ABSTRACT: We identified two phenotypically and functionally distinct populations in AML-iPSC lines upon hematopoietic differentiation. A cell fraction with a hematopoietic stem cell (HSC) immunophenotype exhibiting adherent growth (iLSCs =samples A) and a fraction of more differentiated cells growing in suspension (iBlasts =samples S). We used RNA-seq and ATAC-seq analyses to identify molecular differences between the two populations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE124966 | GEO | 2020/01/11

REPOSITORIES: GEO