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Translational profiling of proximal tubule in fibrotic kidney

ABSTRACT: Injury to the proximal tubule plays a central role in the initiation and progression of kidney fibrosis, and rates of chronic kidney disease progresses approximately 50% faster in males compared to females. We applied Translating Ribosome Affinity Purification (TRAP) followed by RNA-sequencing to characterize the cell-specific proximal tubule transcriptional landscape during fibrosis in male vs. female mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE125015 | GEO | 2019/09/21

REPOSITORIES: GEO

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