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Impact on erythroid progenitor type on erythroid differntiation

ABSTRACT: We sought to compare mature iRBCs derived from WT or SCA hiPSCs to characterize observable disease phenotypes in culture. We performed bulk mRNA sequencing on PB cRBCs, WT iRBCs and SCA iRBCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125196 | GEO | 2019/01/22

REPOSITORIES: GEO

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Tet2-/-Flt3ITD and WT stem and progenitor cells

Project description:The study was a comparison of gene expression using RNA-seq. We analyzed the stem and progenitor cells from WT and Vav-cre+ Tet2fl/fl Flt3-ITD (T2F3) mice. We isolated stem cells LSK (lin- sca+ kit+) and granulocyte-macrophage progenitors GMP (lin- sca- kit+ fcgr+ cd34+) cells from bone marrow. Comparisons were made across genotypes WT vs. T2F3 and cell types LSK vs. GMP.

2015-05-01 | GSE57244 | GEO

Tet2-/-Flt3ITD and WT stem and progenitor cells

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Impact on erythroid progenitor type on erythroid differntiation

Project description:Impact on erythroid progenitor type on erythroid differntiation

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Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells.

Project description: Not available

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Impact of Developmental Lead Exposure on Splenic Factors

Project description:This study focuses on the impact of developmental Pb exposure on splenic gene expression. Pb exposure from gestational day 8 (gd8) to post-natal day 21 (pnd21) was used to obtain insight into how Pb induces anemia and negatively influences the immune response Keywords: exposure analysis

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Differential gene expression in miR-146a-/- vs. WT hematopoietic stem and progenitor cells [miR146aKO_vs_WT_RNA-seq_bulk]

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2020-05-14 | GSE148990 | GEO

aHDF- and PB-iPSC clones from the same individuals

Project description:Hepatocytes generated from human induced pluripotent stem cells (hiPSCs) are unprecedented resources for pharmaceuticals and cell therapy. However, little attention has so far been paid to variations among hiPSC lines in terms of their hepatic differentiation. We developed an improved hepatic differentiation protocol and compared multiple hiPSC lines. This comparison indicated that the hepatic differentiation propensity varies among sibling hiPSC clones derived from the same adult human dermal fibroblasts (aHDFs). In addition, hiPSC clones derived from peripheral blood cells (PB-iPSCs) consistently showed good hepatic differentiation efficiency, whereas many hiPSC clones from adult dermal fibroblasts (aHDF-iPSCs) showed poor hepatic differentiation. However, when we compared hiPSCs from blood and dermal fibroblasts from the same individuals, we found that variations in hepatic differentiation were largely attributable to donor differences, rather than to the types of the original cells. In order to understand the molecular mechanisms underlying the observed variations in hepatic differentiation, we performed microarray analyses of sibling aHDF-iPSC clones, and aHDF- and PB-iPSC clones from the same individuals. Undifferentiated aHDF- and PB-iPSCs from the same individuals (two Parkinson’s disease patients (PD #1 and PD #2) and one adult healthy donor (donor91))

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Specific, Durable and Accurate Gene Expression Signatures of Radiation Response in Mice and Humans

Project description:Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Keywords: peripheral blood, gene expression study, radiation reponse

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CTCF deletion alters the pluripotency and DNA methylation profile of human iPSCs (ChIP-Seq)

Project description:ChIP-Seq analysis of CTCF enrichment in WT hiPSCs and hiPSCs with CTCF deletion

2023-11-24 | GSE247425 | GEO

Transcription profiles of WT and CreER-Raptor-flox/flox common myeloid progenitors (CMP), granulocyte-macrophage progenitor (GMP), or lineage negative (Lin-) stimulated with M-CSF for 12 hours

Project description:Myelopoiesis is impaired in Raptor-deleted mice (CreER-Rptor-flox/flox). To evaluate the transcriptional changes in myeloid precursors , we isolated CMP (Lin–Sca-1–c-Kit+CD34+FcγRII/IIImid), GMP (Lin–Sca-1–c-Kit+CD34+FcγRII/IIIhigh) and Lin (B220, Ly6C, Ly6G, CD3, Ter-119) negative cells (Lin–) from bone marrow of WT or CreER-Rptor-flox/flox mice. RNA was isolated from CMP and GMP immediately after sorting and Lin- cells were cultured for 12 hours with M-CSF (10 ng/mL) in 10% FBS and 1% P/S DMEM before RNA isolation. We used microarrays to compare the global transcription profiles of CMP, GMP, or Lin– stimulated with M-CSF for 12 hours from WT and CreER-Raptor-flox/flox mice.

2017-07-31 | GSE100256 | GEO

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