Modelling G2019S-LRRK2 sporadic Parkinson’s disease in 3D midbrain organoids

ABSTRACT: Recent advances in generating 3 dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling. In this study, we generate isogenic 3D midbrain organoids with or without a Parkinson’s disease-associated LRRK2 G2019S mutation. LRRK2-G2019S midbrain organoids derived from LRRK2 targeted human iPSCs in vitro have LRRK2-associated sporadic Parkinson's disease phenotypes. Midbrain-like 3D organoids expressing LRRK2-G2019S showed dynamic changes in globle gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125234 | GEO | 2019/02/02

REPOSITORIES: GEO