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YB-1 knock.down - siRNA driven YBX1 knock.down

ABSTRACT: The transcription factor and RNA-interacting Y-box binding protein-1 (YB-1 protein, YBX1 gene) has gained interest as a prognostic biomarker and therapeutic target in various malignancies including prostate cancer. Using a custom prostate-cancer-focussed microarray platform, we have established a transcriptome-wide profile of YB-1 target transcripts in the androgen sensitive prostate cancer cell line LNCaP, including RNAs regulated by YB-1 at the post-transcriptional level; under androgen deprived culture conditions and following stimulation with dihydrotestosterone (DHT).

ORGANISM(S): Homo sapiens

PROVIDER: GSE125339 | GEO | 2022/01/17

REPOSITORIES: GEO

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