N6-methyladenosine (m6A) profiling in 60 YRI LCLs

ABSTRACT: N6-methyladenosine (m6A), the most abundant messenger RNA (mRNA) modification, has emerged as a critical post-transcriptional mechanism that regulates various aspect of mRNA metabolism including pre-mRNA processing, mRNA export, mRNA stability and translation efficiency. However the genetics basis of m6A is largely unexplored. In this work, we mapped m6A-QTLs in 60 LCLs and used the resulting tens of thousands of QTLs to provide insights to m6A biology and its contribution to human complex trait.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125377 | GEO | 2020/05/04

REPOSITORIES: GEO