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5-aza-2'-deoxycytidine alters DNA methylation patterns on a genome-wide scale.

ABSTRACT: However, that work lacked direct evidence of the effects of 5-aza-dC on DNA methylation, and indeed the effect of the chemical has since been questioned in Nasonia. Here, using whole-genome bisulphite sequencing of more than 4 million CpGs, across more than 11,000 genes, we demonstrate unequivocally that 5-aza-dC disrupts methylation on a large scale across the Nasonia vitripennis genome.

ORGANISM(S): Nasonia vitripennis

PROVIDER: GSE125388 | GEO | 2019/01/22

REPOSITORIES: GEO

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