DNA methylation analysis of astroblastomas

ABSTRACT: Astroblastomas represent rare cerebral tumors of the central nervous system (CNS). The status of astroblastoma as a distinct molecular entity is controversial, largely because the molecular features of astroblastomas have not been comprehensively evaluated. Herein, we used methylation profiling to compare the signatures of astroblastoma to a reference cohort of brain tumor entities. We found that astroblastomas are molecularly heterogenous and share molecular features with known brain tumor entities including plexomorphic xanthoastrocytoma, high-grade neuroepithelial tumor with MN1 abnormalities, as supratentorial ependymomas with RELA fusions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE125450 | GEO | 2019/03/20

REPOSITORIES: GEO