Expression data in 4T1 cells after co-culture with murine PI/AI BMDM macrophages

ABSTRACT: Macrophages can exert both pro- and anti-tumorigenic features. Interaction between tumour-associated macrophages and tumour cells trigger signalling mechanisms affecting gene expression patterns in both cells. Changes in tumor gene expression affect essential physiological processes such as metabolism, proliferation or adhesion that can lead to an increased invasive and metastatic potential. We used microarrays to detail the global program of gene expression in tumour cells after pro-inflammatory (anti-tumorigenic, M1 or PI) or anti-inflammatory (pro-tumorigenic, M2 or AI) and identified distinct classes of down-regulated genes during this process.

ORGANISM(S): Mus musculus

PROVIDER: GSE125457 | GEO | 2020/06/24

REPOSITORIES: GEO