Genomics

Dataset Information

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Epigenome-wide study of widespread hypomethylated loci associated with early-onset preeclampsia


ABSTRACT: For understanding the relationship of preeclampsia and placental methylation,we performed an epigenome-wide association study in a Chinese cohort containing 22 early-onset preeclampsia patients and 20 normal controls. We used Illumina Infinium HumanMethylation450k BeadChip for detecting the methylation level, and used placental genomic DNA as sample. most of the significant CpG sites were hypomethylated in EOPE in the Chinese cohort. Overall design: placental genomic DNA from 22 early-onset preeclampsia patients and 20 normal controls was bisulfate converted in 450k platform and measured with Illumina HiScan.

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

ORGANISM(S): Homo sapiens  

SUBMITTER: Xinzhi Zhao  

PROVIDER: GSE125605 | GEO | 2019-06-30

REPOSITORIES: GEO

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Publications

Epigenome-wide association data implicate fetal/maternal adaptations contributing to clinical outcomes in preeclampsia.

Wang Teng T   Xiang Yuqian Y   Zhou Xinyao X   Zheng Xiaoguo X   Zhang Huijuan H   Zhang Xiaojing X   Zhang Junyu J   He Lin L   Zhao Xinzhi X  

Epigenomics 20190516 9


<b>Aim:</b> To investigate the changes of placental DNA methylome in preeclampsia (PE). <b>Materials & methods:</b> We performed an epigenome-wide association study in a Chinese cohort and six published datasets consisting of 335 samples in total. <b>Results & conclusion:</b> Numerous consistently hypomethylated probes were associated with early-onset PE in different populations, with 2125 reaching epigenome-wide significance. The validated probes were enriched for cytosine-phosphate-guanine din  ...[more]

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