The effect pregnane receptor X (PXR) agonist PCN on hepatic gene expression in mouse liver with and without glucose

ABSTRACT: The mice were treated i.p. with pregnenolone-16-α-carbonitrile (PCN, 50mg/kg dissolved in DMSO-corn oil 1:3) or vehicle (DMSO-corn oil 1:3) once daily for four days. The mice were fasted for four hours and then administered glucose (2g/kg) by oral gavage or further kept on fasting. The mice were sacrificed 1 hour after glucose administration.

ORGANISM(S): Mus musculus

PROVIDER: GSE125695 | GEO | 2019/11/25

REPOSITORIES: GEO