Genomics

Dataset Information

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Transcriptomic responses and Chromatin accessibility of human monocyte-derived dendritic cells to infection with HIV-1


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Mickael Mathieu Menager  

PROVIDER: GSE125919 | GEO | 2020-01-24

REPOSITORIES: GEO

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Publications


Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing with innate activation remain poorly understood. During HIV-1 infection, human dendritic cells (DCs) can detect the virus through an innate sensing pathway, leading to antiviral interferon and DC maturation. Here, we develop an iterative experimental and computational approach to map the HIV-1 innate response circuitry in monocyte-derived DC  ...[more]

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