Dysregulated RPB1 is a targetable master driver of overgrowth in acute myeloid leukemia.

ABSTRACT: Dysregulated RPB1 is a critical oncogenic hub that drives overgrowth hijacking an array of oncogenic and anti-apoptosis factors.Targeting RPB1 leads to potent regression of human refractory AML in mouse models.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126000 | GEO | 2020/02/01

REPOSITORIES: GEO