Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

ABSTRACT: Previous study has shown that alpha1ACT is a transcription factor involved with regulating neuronal gene expression. We performed a time-series RNA-seq study using pc12 cell lines stably expressing pcDNA3-alpha1ACT at 4 time points (6hr, 24hr, 3day, and 10day) to explore the transcriptional profiles that capture transient and prolonged dynamic changes regulated by alpha1ACT during cell cycle and differentiation

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE126087 | GEO | 2019/02/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

Project description:Previous study has shown that alpha1ACT is a transcription factor involved with regulating neuronal gene expression. We further performed ChIP-seq using pc12 cell lines stably expressing pcDNA3-alpha1ACT or control pcDNA3 vectors to identify genomic locus directly occupied by alpha1ACT

2019-02-06 | GSE126088 | GEO

?1ACT Is Essential for Survival and Early Cerebellar Programming in a Critical Neonatal Window.

Project description: Not available

| S-EPMC6533132 | biostudies-literature

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-02-06 | GSE126089 | GEO

RNA-seq 6 day timecourse for K562 cells grown in hypoxia/normoxia (21%, 5%, 1% oxygen)

Project description:K562 cells were grown at different oxygen levels (21%, 5%, 1%) and samples were collected at 6hr, 24hr, 3day, and 6day time points (triplicate per time point).

2020-01-31 | GSE144527 | GEO

Novel data integration approaches identify concordant and discordant immune responses between mice and humans [human cells]

Project description:We have conducted experiments to compare transcriptional response to tuberculosis (TB) in THP1 cells in time points 1hr,6hr and 24hr after infection.

2017-09-21 | GSE89391 | GEO

Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate

Project description:Whole genome expression profiling in the presence and absence of annexin A2 [shRNA] identified fundamentally altered transcriptional programming that changes the radioresponsive transcriptome. Bioinformatics predicted that silencing AnxA2 may enhance cell death responses to stress in association with reduced activation of pro-survival signals such as nuclear factor kappa B. This prediction was validated by demonstrating a significant increase in sensitivity toward tumor necrosis factor alpha induced cell death in annexin A2 silenced cells, relative to vector controls, associated with reduced nuclear translocation of RelA (p65) following tumor necrosis factor alpha treatment. Murine progenitor cells, JB6 cell line, were stably transformed with Annexin A2 shRNA or vector only control and then treated with ionizing radiation at two doses, 10cGy and 100cGy. Samples were collected at 2hr, 6hr and 24hr for RNA isolation. Two untreated time points were collected also: 2hr and 24hr.

2012-11-28 | E-GEOD-42547 | biostudies-arrayexpress

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window

| PRJNA521000 | ENA

Identification of differential signaling cues in insulin/IGF1 signaling pathways in breast cancer

Project description:Temproral networks of (phospho)-proteins are constructed and analyzed to infer differential interactions under insulin and IGF1 stimulation. In total, 134 antibodies are tested in 21 breast cancer cell lines. The experiments are done in triplicate. Three serum-free-condition time points (5min, 24hr, 48hr) and six stimulation time points (5min, 10min, 30min, 6hr, 24hr, and 48hr) are obtained with either 10 nM IGF1 or 10 nM insulin stimulation.

2016-07-21 | E-GEOD-80233 | biostudies-arrayexpress

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [ChIP-Seq]

| PRJNA521004 | ENA

α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

Project description:α1ACT is essential for survival and early cerebellar programming in a critical neonatal window [RNA-Seq]

| PRJNA521003 | ENA