Dataset Information


Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation

ABSTRACT: Our study reveals up-regulation of the TAK1 pathway when compared with the uninjured hindlimb in our model of trauma-induced heterotopic ossification (tHO) consisting of hindlimb Achilles’ tendon transection with dorsal burn injury. Overall design: Using a model of musculoskeletal injury, we sought to determine the role that TGF-β activated kinase 1 (TAK1) signaling has on MSC cellular differentiation and inappropriate tissue formation (heterotopic ossification).

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Rajasree Menon  

PROVIDER: GSE126118 | GEO | 2019-06-10


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Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of transforming growth factor-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inact  ...[more]

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