Genomics

Dataset Information

4

Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation


ABSTRACT: Our study reveals up-regulation of the TAK1 pathway when compared with the uninjured hindlimb in our model of trauma-induced heterotopic ossification (tHO) consisting of hindlimb Achilles’ tendon transection with dorsal burn injury. Overall design: Using a model of musculoskeletal injury, we sought to determine the role that TGF-β activated kinase 1 (TAK1) signaling has on MSC cellular differentiation and inappropriate tissue formation (heterotopic ossification).

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Rajasree Menon  

PROVIDER: GSE126118 | GEO | 2019-06-10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE126118_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image

Publications


Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of transforming growth factor-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inact  ...[more]

Similar Datasets

2019-01-01 | S-EPMC6542699 | BioStudies
1000-01-01 | S-EPMC6302947 | BioStudies
2020-01-01 | S-EPMC7314999 | BioStudies
2020-01-01 | S-EPMC7428569 | BioStudies
1000-01-01 | S-EPMC5542633 | BioStudies
1000-01-01 | S-EPMC2699391 | BioStudies
1000-01-01 | S-EPMC2586273 | BioStudies
2019-01-01 | S-EPMC6848966 | BioStudies
2020-01-01 | S-EPMC7002453 | BioStudies
1000-01-01 | S-EPMC5059887 | BioStudies