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Genome-wide analysis of gene expression in proliferative dentate gyrus (DG) nuclei of adult wild-type and KMT2D-deficient mice

ABSTRACT: We conducted genome wide transcription profiling by RNA-seq in proliferating neuronal progenitors after purifying EdU+ nuclei from micro-dissected DG of adult wild-type and KMT2D-deficient mice (Kmt2d +/Bgeo)

ORGANISM(S): Mus musculus

PROVIDER: GSE126164 | GEO | 2019/02/07

REPOSITORIES: GEO

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Genome-wide analysis of gene expression in proliferative dentate gyrus (DG) nuclei of adult wild-type and KMT2D-deficient mice

Project description:Genome-wide analysis of gene expression in proliferative dentate gyrus (DG) nuclei of adult wild-type and KMT2D-deficient mice

| PRJNA521223 | ENA

ECS-induced gene expression changes in mouse dentate gyrus

Project description:Neuronal activity-dependent gene expression plays important roles in neural plasticity. We use electroconvulsive stimulation (ECS) as an in vivo model for neuronal activation to identify genes that are regulated by neuronal activity. Dentate gyri (DG) were microdissected 4 hours after sham or ECS treatment for gene expression profiling. 4 total samples were analysed (2 for each condition). Averaged expression values between sham and ECS samples were pair-wise compared.

2011-08-31 | E-GEOD-30493 | biostudies-arrayexpress

iTRAQ-based proteomic analysis of dentate gyrus in temporal lobe epilepsy with hippocampal sclerosis

Project description:Temporal lobe epilepsy (TLE) is the most frequent type of focal epilepsy in adults, typically resistant to pharmacological treatment and mostly present with cognitive impairment and psychiatric comorbidities. The most common neuropathological hallmark in TLE patients is hippocampal sclerosis(HS). However, the underlying molecular mechanisms involved remain poorly characterized. Dentate gyrus(DG), one specific hippocampal subarea, structural and functional changes imply a key involvement of the DG in the development of TLE. In this study, isobaric tags for relative and absolute quantitation (iTRAQ) -based quantitative proteomic technique was performed to analysis of hippocampal DG obtained from patients with TLE-HS compared to control samples obtained from the autopsy. Our proteomic data identified 5583 proteins, of which 82 proteins were up-regulated and 90 proteins were down-regulated. Bioinformatics analysis indicated that differential expressed proteins enriched in “synaptic vesicle”, “mitochondrion”, “cell-cell adhesion”, “regulation of synaptic plasticity”, “ATP binding” and “Oxidative phosphorylation”. Protein-protein interaction network analysis found a pivotal module of 10 proteins that relate to “Oxidative phosphorylation”. This study is the first to investigate proteomic alterations in DG region of TLE-HS patients, and pave the way to better understanding of epileptogenesis mechanisms and future therapeutic intervention.

2021-01-18 | PXD023048 | Pride

Sox11 - a novel activity-regulated gene with dentate gyrus-specific expression

Project description:Neuronal activity initiates transcriptional programs that shape long-term changes in plasticity. Although neuron subtypes differ in their plasticity response, most activity-dependent transcription factors are broadly expressed across different neuron subtypes and brain regions. Thus, how regional and neuronal subtype-specific plasticity are established on the transcriptional level remains poorly understood. Here, we report that the developmental transcription factor Sox11 is induced in mature neurons upon hippocampal circuit activity and that this activity-dependent expression occurs exclusively in the dentate gyrus (DG) of the hippocampus. In addition, we show that Sox11 can modify synaptic plasticity and intrinsic excitability of DG granule cell neurons as well as the expression of plasticity-related genes. We propose that Sox11 is a DG-specific activity-dependent gene and might play a role in fine tuning regional plasticity in the hippocampal circuit.

2019-11-10 | GSE140180 | GEO

RNA-Seq data from V321L mouse dentate gyrus (DG)

Project description:Schizophrenia is a complex genetic neurodevelopmental disorder. eQTLs form bulk of the genetic variation contributing to schizophrenia. However, there is no known mechanism explaining regulation of expression of eQTL associated risk genes and underlying neurodevelopmental processes that are part of the cellular pathology. Neuregulin1-ErbB4 signaling plays a crucial role in synaptogenesis and has been implicated in schizophrenia. Gamma secretase mediated NRG1 nuclear back-signaling is thought to be involved in transcriptional regulation. A psychosis-associated missense mutation in NRG1 (rs74942016) has been predicted to impair nuclear back-signaling thereby implicating this mode of signaling in the underlying cellular pathology.

2023-12-31 | GSE192869 | GEO

ECS-induced gene expression changes in mouse dentate gyrus

2011-09-01 | GSE30493 | GEO

Whole transcriptome analysis of postmortem human hippocampus dentate gyrus granlule cells

Project description:We investigated the transcriptome of dentate gyrus (DG) granule cells in postmortem hippocampus from 79 subjects with mental illness (schizophrenia, bipolar disorder, major depression) or non-psychiatric controls.

2014-04-09 | GSE42546 | GEO

Extrinsic factors facilitate neurogenesis in a human induced pluripotent stem cell-derived model of the dentate gyrus

Project description:Modeling development and maturation of the human hippocampus in culture is crucial to elucidate the physiological and pathological mechanisms of its neurogenesis. We established human hippocampal cell cultures by means of controlled neuralization of human induced pluripotent stem cells (hiPSCs). The timely re-activation of WNT signaling in hiPSCs, which were previously driven toward a dorsal telencephalic identity by the combined inhibition of WNT, BMP and TGF-β signaling, produced neural progenitors with a gene expression signature typical of human embryonic dentate gyrus (DG) cells. Key markers of neurogenesis resulted downstream of the NOTCH and WNT pathway and were upregulated in these progenitors. Notably, we found that, in addition to continuous WNT signaling, a specific laminin isoform is crucial to prolonging DG stem state and to extend DG progenitor proliferation for over 200 days in vitro. In fact, transition from laminin 511 to mouse laminin inhibited cell proliferation and promoted the differentiation of DG cells. Interestingly, global gene expression profiles of early and late progenitor cells and neurons suggest that a niche of laminin 511 and WNT signaling is sufficient to maintain a cell population enriched in DG progenitor cells and neurons. Finally, the xenograft of human DG progenitors into the DG of adult immunosuppressed host mice produced efficient integration of neurons, which innervated CA3 layer cells with an area covered by synapses similar to the area covered by endogenous hippocampal neuron synapses. Our observations indicate that neurons produced in the established culture niche resemble bona-fide human DG neurons.

2022-08-22 | GSE199355 | GEO

Effect of methanol fixation on single cell RNA sequencing of the murine dentate gyrus.

Project description:We evaluated the effect of methanol (MeOH) fixation on adult murine dentate gyrus (DG) single cell suspensions.

2023-09-22 | GSE232052 | GEO

DG vs superficial gonorrhoeae comparisons

Project description:transcription profiles of two groups each containing 5 strains of Disseminated gonorrhoeae (DG) and Undisseminated (superficial) gonorrhoeae (UG) were compared. An additional set of comparisons was done between 4 strains from group one Disseminated gonorrhoeae (DG) and another 4 strains from the same group.

2012-06-15 | E-MEXP-3254 | biostudies-arrayexpress

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