Mismatch-repair signature mutations activate gene enhancers across human colorectal cancer epigenomes

ABSTRACT: We show that mismatch-repair (MMR) signature mutations can activate colorectal cancer (CRC)-specific enhancers, through analysis of enhancer DNA associated with the active enhancer histone mark H3K27ac. We demonstrate that MMR mutations activate enhancers using a xenograft metastasis model, where mutations are induced naturally via CRISPR/Cas9 inactivation of MLH1 prior to tumor cell injection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126188 | GEO | 2019/02/07

REPOSITORIES: GEO