RNAseq analysis of glomerular transcriptome of wild-type vs. Podocyte Cosmc knockout

ABSTRACT: Cosmc is an obligate chaperone for C1GalT1 T transferase necessary for generating mature mucin-type O-glycans. Animals lacking Cosmc in glomerular podocytes develop proteinuria, glomerulosclerosis and progressive renal failure. This study was designed to examine transcriptome differences in 1 month male animals with and without podocyte Cosmc, a time point when proteinuria is established but glomerular architecture is still relatively intact.

ORGANISM(S): Mus musculus

PROVIDER: GSE126217 | GEO | 2019/03/04

REPOSITORIES: GEO