Transcriptome analysis after disruption of nuclear F-actin in mouse embryos

ABSTRACT: We find that filamentous actin (F-actin) is formed in pronuclei of mouse zygotes, disruption of which resulted in abnormal development of mouse embryos. To further explain the molecular mechanism, transcriptome analysis was performed following the artificial disruption of nuclear F-actin by overexpression of mutant actin R62D or G15S in nuclei.

ORGANISM(S): Mus musculus

PROVIDER: GSE126317 | GEO | 2020/06/30

REPOSITORIES: GEO