Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Copy number analysis of selumetinib-resistant CRC cells lines

ABSTRACT: Copy number analysis to compare parental colorectal cancer cell lines and their selumetinib-resistant derivatives and identify gene copy changes that might contribute to resistance

ORGANISM(S): Homo sapiens

PROVIDER: GSE126367 | GEO | 2019/03/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

RNA sequencing analysis of selumetinib-resistant CRC cells lines

Project description:RNA sequencing analysis to compare parental colorectal cancer cell lines and their selumetinib-resistant derivatives and identify expression changes and/or mutations that might contribute to resistance

2019-03-11 | GSE126109 | GEO

Copy number analysis of selumetinib-resistant CRC cells lines

Project description:Copy number analysis of selumetinib-resistant CRC cells lines

| PRJNA521709 | ENA

Selumetinib

Project description:Selumetinib

| PRJNA712989 | ENA

RNA sequencing analysis of selumetinib-resistant CRC cells lines

Project description:RNA sequencing analysis of selumetinib-resistant CRC cells lines

| PRJNA521036 | ENA

Gene copy number variation profiling by microarray

Project description:Here, we investigate focal amplification patterns in and around the BRAF locus in BRAFV600Emutant COLO205 cells that acquire resistance to the MEK inhibitor Sleumetinib / AZD6244 / ARRY-142886. We find that BRAF amplifications occur frequently in COLO205 cells during acquisition of selumetinib resistance and that BRAFamplifications pre-exist selumetinib treatment but occurs predominantly via de novo mutations

2021-03-23 | GSE168603 | GEO

FFPE study using MIP copy number platform

Project description:This SuperSeries is composed of the following subset Series: GSE14740: FFPE study using MIP copy number platform - kidney GSE14741: FFPE study using MIP copy number platform - bladder/colorectal/kidney/liver GSE14742: FFPE study using MIP copy number platform - colorectal GSE14743: FFPE study using MIP copy number platform - breast cancer I GSE14744: FFPE study using MIP copy number platform - breast cancer II GSE14745: FFPE study using MIP copy number platform - liver Refer to individual Series, GSE14856_quartets.txt contains list of matched samples

2010-05-06 | E-GEOD-14856 | biostudies-arrayexpress

M249 melanoma cells: Vemurafenib and Selumetinib resistant through BRAF double minutes vs. parental

Project description:CGH profiling of M249 melanoma cell line treated with step-wise increasing Vemurafenib and Selumetinib to develop resistance (VSR). The resistance mechanims was through BRAF amplification in double minute (DM) format. The control cell line is untreated M249.

2021-12-20 | GSE153526 | GEO

M249 melanoma cells: Vemurafenib and Selumetinib resistant through BRAF double minutes vs. parental

Project description:M249 melanoma cells: Vemurafenib and Selumetinib resistant through BRAF double minutes vs. parental

| PRJNA642898 | ENA

Copy number profiling of 5-FU resistant gastric cancer cell line compared to the parental cell line

Project description:Copy number profiling of MKN45T 5-FU resistant gastric cancer cell lines and its parental cell line MKN45. We hypothesized that a detailed fine-scale survey of genomic CNAs might reveal the mechanism for acquired resistant to 5-FU in gastric cancer.

2017-06-09 | GSE89191 | GEO