RNAseq analysis of Huh7 cells upon stable-knockdown of L1 elements

ABSTRACT: L1 elements are repeat elements known to get activated during hepatocarcinogenesis. We have knocked-down expression of L1 elements using shRNA targeting L1-ORF1 in Huh7 cell line and a control non-targeting cell line was also generated. Influence of L1 knockdown on overall cellular transcritome was then analysed by RNAseq followed by pathway analysis. Overall, a crosstalk between L1 elements and TGFbeta signaling pathway is observed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE126615 | GEO | 2023/01/21

REPOSITORIES: GEO