Tanycyte-independent control of hypothalamic leptin signaling

ABSTRACT: Purpose: 1. Bulk-RNA-Seq was performed to identify tancytye-enriched genes. 2. scRNA-Seq was performed to profile hypothalamic cells following leptin treatment Conclusions: Leptin receptor expression in tanycytes is either absent or undetectably low, that tanycytes do not directly regulate hypothalamic leptin signaling, and that leptin regulates gene expression in diverse hypothalamic cell types through both direct and indirect mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE126707 | GEO | 2019/02/19

REPOSITORIES: GEO