Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells

ABSTRACT: Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional and epigenetic memory in virus-specific CD8 T cells. These findings suggest a general mechanism for the formation of epigenetic memory in CD8 T cells and other immune and non-immune cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE126770 | GEO | 2019/05/21

REPOSITORIES: GEO