Transcriptomics

Dataset Information

0

A missense mutation in AIOLOS causes B cell deficiency by interfering with IKAROS


ABSTRACT: A missense mutation (G158R) in Ikzf3 gene resulted in defective generation of B cells in mice. Pre-B cells were profoundly decreased in homozygous mutant mice. Heterozygous mutant mice showed milder B cell developmental defects, and decreased B cells in the secondary lymphoid organs were observed. Ikzf3 encodes Aiolos, which makes heterodimer with Ikaros. Our findings indicate that the loss-of-function mutation in Aiolos hinders B cell development by interfering Ikaros' function via formation of heterodimers.

ORGANISM(S): Mus musculus

PROVIDER: GSE126778 | GEO | 2022/02/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-05-01 | GSE167487 | GEO
2023-10-20 | GSE220020 | GEO
2023-10-20 | GSE220022 | GEO
2023-10-20 | GSE220021 | GEO
2023-10-20 | GSE220028 | GEO
| PRJNA523246 | ENA
2018-09-12 | GSE113031 | GEO
2022-07-12 | GSE201324 | GEO
2023-08-02 | GSE234649 | GEO
| PRJNA704728 | ENA