Dataset Information


TNFa and LTB stimulated UM-SCC 46 gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HumanWG-6 v3.0 expression beadchip (gene symbol)

SUBMITTER: Carter Van Waes  

PROVIDER: GSE126905 | GEO | 2019-02-22


Dataset's files

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Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.

Das Rita R   Coupar Jamie J   Clavijo Paul E PE   Saleh Anthony A   Cheng Tsu-Fan TF   Yang Xinping X   Chen Jianhong J   Van Waes Carter C   Chen Zhong Z  

Molecular carcinogenesis 20181128 3

Head and neck squamous cell carcinomas (HNSCC) preferentially spread to regional cervical tissues and lymph nodes. Here, we hypothesized that lymphotoxin-β (LTβ), receptor LTβR, and NF-κB-inducing kinase (NIK), promote the aberrant activation of alternative NF-κB2/RELB pathway and genes, that enhance migration and invasion of HNSCC. Genomic and expression alterations of the alternative NF-kB pathway were examined in 279 HNSCC tumors from The Cancer Genome Atlas (TCGA) and a panel of HNSCC lines.  ...[more]

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