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The regeneration transcriptome of corticospinal neurons

ABSTRACT: In the present study, we identify transcriptional mechanisms associated with corticospinal regeneration. We took advantage of the ability of NPC grafts to support corticospinal regeneration, together with a genetic mouse model (Glt25d2-GFP-L10a mice, in which a bacterial artificial chromosome (BAC) codes for GFP-tagged polyribosomes in layer 5b cortical neurons) to selectively enrich actively translated mRNA pools from layer Vb cortical projection neurons containing corticospinal neurons (Doyle et al., Cell 2008).

ORGANISM(S): Mus musculus

PROVIDER: GSE126957 | GEO | 2020/01/21

REPOSITORIES: GEO

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The regeneration transcriptome of corticospinal neurons

Project description:The regeneration transcriptome of corticospinal neurons

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