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Identification of herpes simplex virus 1 and host targets of miR-138 by combined RNAseq/PARCLIP

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Human alphaherpesvirus 1 Homo sapiens

PROVIDER: GSE127504 | GEO | 2020/04/27

REPOSITORIES: GEO

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Identification of herpes simplex virus 1 and host targets of miR-138 by combined RNAseq/PARCLIP

Project description:Identification of herpes simplex virus 1 and host targets of miR-138 by combined RNAseq/PARCLIP

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Project description:Like herpes simplex virus 1 (HSV-1) ICP0 mRNA, HSV-2 ICP0 mRNA is predicted to be targeted by a host neuron-specific microRNA, miR-138. This study was designed to confirm the interaction between HSV-2 ICP0 mRNA and miR-138, and to identify other potential viral and host targets of miR-138 during HSV-2 infection. We performed PAR-CLIP on HSV-2 infected 293T cells overexpressing miR-138 in comparisin to control 293T cells. The results confirmed ICP0 as miR-138's targets, and also identified some other potential viral and host targets of miR-138.

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Identification of herpes simplex virus 1 and host targets of miR-138 by comparative PAR-CLIP in Neuro-2a and 293T cells

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Houttuynia cordata targets the beginning stage of herpes simplex virus infection.

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Herpes simplex host shutoff attenuates antiviral state

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