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Molecular signature of asthma-enhanced sensitivity to aerosols of pristine and carboxylated CuO nanoparticles, identified in 3D cell models.

ABSTRACT: Via extensive comparative analysis of 3D human bronchial epithelial model (MucilAirTM) exposed to air or CuO-based aerosols, we show that existence of asthma enhances sensitivity of the airways to nanoparticles, possibly as a combined result of a hyperactive airway and inefficient mucociliary clearance mechanisms in asthmatics.

ORGANISM(S): Homo sapiens

PROVIDER: GSE127773 | GEO | 2019/05/01

REPOSITORIES: GEO

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