Gene expression changes in HT-22 cells with or without PGC-1α overexpression upon OGD stimulation

ABSTRACT: PGC-1α overexpression in neurons protects against chronic cerebral hypoperfusion-induced cognitive impairment in mice. To investigate the neuroprotective mechanism of PGC-1α, we employed RNA-Seq analysis on PGC-1α-overexpressed HT-22 cells, a hippocampal neuron cell line. We performed OGD experiment to mimick chronic cerebral hypoperfusion. Indeed, PGC-1α overexpression alters the gene expression profiles of HT-22 cells, suggesting that neuronal PGC-1α might play an important role after chronic cerebral hypoperfusion.

ORGANISM(S): Mus musculus

PROVIDER: GSE127788 | GEO | 2019/03/05

REPOSITORIES: GEO