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Complementary transcriptomic analysis of human medullary thymic epithelial cells

ABSTRACT: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very few of them have been identified. We are using a proteogenomic approach, combining RNA-Sequencing and mass spectrometry, to discover TSAs. We performed RNA-Sequencing on human medullary thymic epithelial cells (mTECs) to use them as a "normal control" because they express most known genes and orchestrate T cell selection to induce central tolerance to MHC peptides coded by their vast transcriptome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE127826 | GEO | 2019/11/20

REPOSITORIES: GEO

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