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EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential

ABSTRACT: Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem and cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Ebf1-deficient MSCs have reduced mesenchymal lineage potential. Ebf1 deletion in Cxcl12-abundant reticular (CAR) cells and PDGFRα+Sca1+CD45-CD31-Lin- (PαS) cells in the bone marrow decreased the numbers of HSPCs and myeloid cells. EBF1 in the bone marrow niche regulates a transcriptional program that determines the functional interactions with HSCs and the long-term balance between the myeloid and lymphoid cell fates.

ORGANISM(S): Mus musculus

PROVIDER: GSE127970 | GEO | 2020/03/01

REPOSITORIES: GEO

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EBF1-mutant bone marrow stroma confers long-term changes in hematopoietic stem cell potential [HSC]

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