Ontology highlight
ABSTRACT:
INSTRUMENT(S): [MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript (gene) version]
ORGANISM(S): Mus musculus
SUBMITTER: Guido Hooiveld
PROVIDER: GSE128248 | GEO | 2020-02-20
REPOSITORIES: GEO
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Feoktistova Maria M Makarov Roman R Brenji Sihem S Schneider Anne T AT Hooiveld Guido J GJ Luedde Tom T Leverkus Martin M Yazdi Amir S AS Panayotova-Dimitrova Diana D
Cells 20200203 2
The ubiquitin-editing protein A20 (TNFAIP3) is a known key player in the regulation of immune responses in many organs. Genome-wide associated studies (GWASs) have linked A20 with a number of inflammatory and autoimmune disorders, including psoriasis. Here, we identified a previously unrecognized role of A20 as a pro-apoptotic factor in TNF-induced cell death in keratinocytes. This function of A20 is mediated via the NF-κB-dependent alteration of cIAP1/2 expression. The changes in cIAP1/2 protei ...[more]