Dataset Information


B cell subsets from human tonsil and blood

ABSTRACT: B cells from human tonsil and blood were sorted using flow cytometry. The human samples were processed immediately ex-vivo using markers for known B cell subsets. Overall design: Human B cell subsets from tonsil and blood investigated for analysis with gene expression


INSTRUMENT(S): [HG-U133A] Affymetrix Human Genome U133A Array

SUBMITTER: Dereje D. Jima  

PROVIDER: GSE12845 | GEO | 2008-09-19



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Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.

Longo Nancy S NS   Lugar Patricia L PL   Yavuz Sule S   Zhang Wen W   Krijger Peter H L PH   Russ Daniel E DE   Jima Dereje D DD   Dave Sandeep S SS   Grammer Amrie C AC   Lipsky Peter E PE  

Blood 20081120 16

Subjects with X-linked hyper-IgM syndrome (X-HIgM) have a markedly reduced frequency of CD27(+) memory B cells, and their Ig genes have a low level of somatic hypermutation (SHM). To analyze the nature of SHM in X-HIgM, we sequenced 209 nonproductive and 926 productive Ig heavy chain genes. In nonproductive rearrangements that were not subjected to selection, as well as productive rearrangements, most of the mutations were within targeted RGYW, WRCY, WA, or TW motifs (R = purine, Y = pyrimidine,  ...[more]

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