The transcription Factor Slug represses p16Ink4a and regulates murine muscle stem cell aging

ABSTRACT: Sustainable muscle regeneration necessitates proper maintenance of the quiescence-reversible SCs pool. Activation of p16Ink4a-associated senescence pathway during aging breaks muscle homeostasis and causes degenerative muscle disease by irreversibly dampening satellite cell (SC) self-renewal capacity. We performed microarrays analysis to compare the genome-wide gene expression profiles of wild-type and Slug-deficient SCs and identified distinct classes of up-regulated genes upon deletion of Slug gene.

ORGANISM(S): Mus musculus

PROVIDER: GSE128507 | GEO | 2019/03/20

REPOSITORIES: GEO