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Crosstalk from Non-Cancerous Mitochondria Can Inbibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

ABSTRACT: Microarray analysis suggested that several oncogenic pathways observed in cybrids with cancer mitochondria are inhibited in cybrids with non-cancerous mitochondria. These results suggest the critical oncogenic regulation by motochondrial-nuclear cross talk and highlights rectifying motochondiral functional properties as a promising target in cancer therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE128610 | GEO | 2019/03/21

REPOSITORIES: GEO

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Crosstalk from Non-Cancerous Mitochondria Can Inbibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

Project description:Crosstalk from Non-Cancerous Mitochondria Can Inbibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

| PRJNA528278 | ENA

Gene expression profiling of transmitochondrial cybrids (triple negative breast cancer cells in SUM159 background)

Project description:We used a transmitochondrial cybrid (cybrids)-based discovery approach to identify mitochondria-regulated cancer pathways in TN BCa. Cybrids were generated under a moderately metastatic TN BCa cell line SUM159 as the common nuclear background with mitochondria from benign breast epithelium (A1N4) and moderately metastatic (SUM159) TN BCa cells. In vitro and in vivo studies suggested that even under the common moderately cancerous nuclear background, mitochondria from benign cells inhibit and metastatic cell induce cancer properties of a moderately aggressive TN BCa cell. Gene expression studies identified c-Src onco-pathway as one of the major cancer pathways altered according to the mitochondria status of the cybrids.

2016-04-14 | GSE72319 | GEO

Gene expression profiling of transmitochondrial cybrids (triple negative breast cancer cells in SUM159 background)

2016-04-14 | E-GEOD-72319 | biostudies-arrayexpress

Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways.

Project description: Not available

| S-EPMC3650012 | biostudies-literature

Correction: Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways.

Project description: Not available

| S-EPMC6706049 | biostudies-literature

RNA Sequencing of transmitochondrial cybrids

Project description:RNA Sequencing of transmitochondrial cybrids revealed a downregulation of oxidative phosphorylation and nicotinamide metabolism in cybrids with patient mitochondria

2022-10-19 | GSE215859 | GEO

Crosstalk between gut microbiota and mitochondria during endurance: a new example of holobiont in mammals

Project description:Endurance exercise has a dramatic impact on the functionality of mitochondria and on the composition of intestinal microbiome, but the mechanisms regulating the crosstalk between these two components are still largely unknown. Here, we sampled 20 elite horses before and after an endurance race and used blood transcriptome, blood metabolome and fecal microbiome to describe the microbiota-mitochondria inter-talk. A subset of mitochondria-related differentially expressed genes involved in pathways such as energy metabolism, oxidative stress and inflammation was discovered and then shown to be associated with butyrate-producing bacteria of the Lachnospiraceae family, especially Eubacterium. The mechanisms involved were not fully understood, but through the action of their metabolites likely acted on PPARδ, the FRX-CREB axis and their downstream targets to delay the onset of hypoglycemia, inflammation and extend running time. Our results also suggested that circulating free fatty acids may act not merely as fuel but drive mitochondrial inflammatory responses triggered by the translocation of gut bacterial polysaccharides following endurance. Targeting the gut-mitochondria axis appears therefore as a potential strategy to enhance athletic performance.

2021-02-09 | GSE163767 | GEO

DNA methylation profile of cancerous and non-cancerous renal tissues

Project description:DNA methylation profile of cancerous and non-cancerous renal tissues

| PRJNA701825 | ENA

Gene expression profile of cancerous and non-cancerous renal tissues

Project description:Gene expression profile of cancerous and non-cancerous renal tissues

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Normal and Cancerous Prostate Cells

Project description:This SuperSeries is composed of the following subset Series: GSE38674: Genomic DNA in Normal and Cancerous Prostate Cells GSE38676: Expression Analysis of Normal and Cancerous Prostate Cells GSE38677: Mapping of Transcription Start Sites of Normal and Cancerous Prostate Cells GSE38682: H3K4me3 Marks in Normal and Cancerous Prostate Cells GSE38683: H3K27me3 Marks in Normal and Cancerous Prostate Cells GSE38684: Chromatin Looping of Normal and Cancerous Prostate Cells Refer to individual Series

2012-10-16 | E-GEOD-38685 | biostudies-arrayexpress

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